最新の学術論文の紹介【No.1】（ナトリウム吸収）

題名：[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa

（和訳：粘膜表面TRPV1受容体を介したジンゲロールに誘発されるアミロライド感受性ナトリウム吸収－ラット大腸における検討－）

◎Yo Tsuchiya and Koichi Kawamata

論文情報：J Nutr Sci Vitaminol，64，p287-291，2018

（※「最新」の定義は掲載日から起算して１年程度としています）

【分析者の視点】

　今回は本学が関わっている学術論文の紹介。健康栄養学専攻の教員である川俣先生と淑徳大学の土谷教授との共同研究の一部が、英文誌「J Nutr Sci Vitaminol」に掲載されましたので、報告いたします。

【論文全体の要約】

　ナトリウムというミネラルが食塩の実態であることは良く知られています。その一方で、このナトリウム吸収を活性化させる、または抑制させるような食品成分が存在することはあまり知られていません。この研究では生姜成分であるジンゲロールがナトリウム吸収を活性化させる可能性を持つことを明らかにしました。

【Abstract】

[6]-Gingerol possesses various beneficial pharmacological and therapeutic properties, including anti-carcinogenic and anti-inflammatory properties and the ability to regulate intestinal contraction. Recently, our group observed that the serosal administration of [6]-gingerol stimulated electrogenic sodium absorption in the rat colon via the capsaicin receptor, TRPV1. TRPV1 is known to be expressed in both the mucosal epithelium and the muscle layers in the colon. In the present study, we assessed whether [6]-gingerol stimulated sodium absorption via TRPV1 in the colonic mucosal epithelium. We compared the effect of [6]-gingerol on TRPV1-dependent colonic sodium absorption in the colon preparation with or without muscle layer. All experiments were performed by measuring the transmural potential difference (ΔPD) in an Ussing chamber system. [6]-Gingerol induced positive ΔPD when administered to the serosal side of the colon, and this effect was significantly larger in the colon preparation without muscle layer than in that with the muscle layer. In the colon preparation without muscle layer, the [6]-gingerol-dependent induction of ΔPD was markedly suppressed by mucosal addition of amiloride, a selective inhibitor of epithelial sodium channel. ΔPD induction by [6]-gingerol was considerably diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1, but not by AP-18, an inhibitor of TRPA1. These results suggest that [6]-gingerol induces amiloride-sensitive electrogenic sodium absorption in the rat colon via TRPV1 expressed in the colonic mucosal epithelium, and that this effect is independent of TRPV1 in the colonic muscle layer.